In a cocaine-intoxicated patient with elevated blood pressure and pulse, what complication is most likely to occur?

Cocaine intoxication can lead to a variety of physiological responses due to its stimulant effects on the central nervous system and its impact on cardiovascular function. One of the most common and significant complications of cocaine use is hyperthermia.

This condition arises from several factors associated with cocaine use, including increased metabolic rate, agitation, and elevated muscle activity, particularly in a sympathetic state induced by the drug. The combination of these factors causes the body's temperature-regulating mechanisms to become overwhelmed, leading to a rise in core body temperature.

Hyperthermia can have serious consequences, including potential organ failure, and is often exacerbated in scenarios where physical exertion is high or when cocaine is used in hot environments. Immediate recognition and treatment of hyperthermia in a cocaine-intoxicated patient are crucial, as it can progress rapidly and lead to serious morbidity.

The other complications listed, such as hypercalcaemia, hyperkalaemia, and hyponatraemia, are less directly associated with cocaine intoxication and are not as commonly seen compared to hyperthermia. Understanding this linkage is important for clinicians when assessing and managing patients with cocaine use disorders.