What is the most appropriate initial treatment for a patient with generalized reddening of the skin and history of psoriasis?

In the context of a patient presenting with generalized reddening of the skin and a history of psoriasis, initiating treatment with oral prednisolone is appropriate. Psoriasis is an immune-mediated condition characterized by skin inflammation, and in cases where there is widespread involvement and significant symptoms, systemic corticosteroids like prednisolone can help rapidly reduce inflammation and control symptoms.

Oral prednisolone works by dampening the immune response and reducing the production of pro-inflammatory cytokines, which are often implicated in psoriasis flares. This can be particularly effective for controlling acute exacerbations where the skin is extensively involved, leading to a potential improvement in the patient’s overall condition.

In contrast, other options may not be as effective in this scenario. Topical treatments like coal tar solution and white soft paraffin are more suitable for localized areas or chronic management rather than initial treatment for generalized rashes. Coal tar is typically used for its anti-inflammatory and keratolytic properties, but it may not provide the rapid relief needed in acute situations. Similarly, white soft paraffin can be beneficial as a moisturizer to prevent dryness and scaling in psoriasis but does not have the efficacy in treating inflammation.

Overall, the choice of oral prednisolone aligns with the need for a prompt and effective